CBD Oil and PTSD


CBD OIL FOR PTSD (Post Traumatic Stress Disorder)

Col. Philip Blair, MD, ret., (US Army)

To our Veterans: thank you for the service, safely and protection you’ve provided us. I can’t even watch a war movie and you’ve potentially lived it. If you haven’t heard of CBD we are having wonderful results with helping PTSD. Dr.Philip Blair has clinical data also. To life with less war, more healing and better health care. Soulfully, thank you.

PTSD

With Dr. Philip Blair, MD, COL
(Retired, US Army)

What will be covered in this article:

  1. What is PTSD and how does it occur?
  2. The Endocannabinoid System (ECS) in health and PTSD
  3. Understanding cannabidiol and how it works
  4. How can CBD improve PTSD
  5. Case Reports of CBD for PTSD
  6. Question and Answer, including contraindications

What is PTSD and how does it occur?

  • PTSD is group of adverse physical, mental and emotional symptoms that commonly occur after exposure to traumatic life events.
  • Common occurrence in civilian and military populations
  • Typical physical, mental and emotional changes
  • Fear memory reconsolidation and extinction
  • Current behavioral and medical treatment approaches

CBD-and-PTSD


Endocannabinoid system (ECS) is widely dispersed with many roles.

  • The ECS consists of a few endogenous lipid like molecules that activate specific cellular receptors.
  • The ECS controls neurologic, endocrine, immune, behavior and cognitive functions.
  • ECS is also activated by foods, drugs, activity, and phytocannabinoids.

ECS Deficiency in PTSD

Endocannabinoid system (ECS) deficiency is common in many diseases.

  • ECS deficiency in PTSD
  • Reduced natural cannabinoids (eCB)
  • Reduced eCB receptors
  • Increased metabolism
  • Response to medical cannabis

 

CB1-Receptors PTSD

What is Cannabidiol and how does it work.

  • From cannabis, two types: marijuana vs hemp, psycho-active vs healthful
  • Legal status
  • CBD functions to restore normal balance
  • CBD interacts with eCS and wide range of cell receptors
  • Key and Lock model
  • Safety, toxicity, drug interactions

How CBD Effects PTSD

  • Blocks reconsolidation memory
  • Enhances extinction learning
  • Blocks Mood Receptors
  • Modulates pain receptors
  • Modulates stress hormones
  • Promotes sleep hormones

CBD in PTSD Case Reports

  • SGT Cote, Infantry, 82 yo Korean War Veteran
  • CPL Jones, 82nd Airborne, Iraq, Recovery Vehicle Operator
  • Other benefits:
    • Communication and relationships
    • Emotional expression
    • Reduces opioid use and addictive behavior
    • Improves sleep

Making a CBD Recommendation

  • CBD sources
  • CBD product forms
  • CBD companies

Suggested Serving Size for PTSD

  • 30 mg twice daily
  • Adjust amount early
  • Re-assess day one and week one

Positive Benefits of Cannabidiol

  • Improved feelings of wellbeing
  • Better mood
  • Improved sleep
  • Increase activity and mobility
  • Improved memory and thinking
  • Improvements in skin & hair
  • Improvements in eyesight, smell and taste
  • Better performance in work and play
  • Improved libido

Conclusion

  • PTSD is common
  • Endocannabinoid dysfunction plays intimate role
  • CBD for treatment and prevention
  • CBD from hemp is legal in all states and internationally

About The Author Dr. Blair

  • Family Physician providing disease management in the US Northwest.
  • Graduated West Point in 1972, obtained MD at the University of Miami in 1978.
  • Career Army Combat Physician, 3rd Armored DISCOM Surgeon for Gulf War 1990-1991.
  • Retired from Army as Colonel in 1996.
  • President, Pro Health Advisor, Inc. – a disease management company.
  • Researched and applied hemp cannabidiol (CBD) to clinical care for patients and health professionals everywhere.

References

  1. Ther Adv Psychopharmacol 2016, Vol. 6(4) 283–295. New avenues for treating emotional memory disorders: towards a reconsolidation intervention for posttraumatic stress disorder
  2. Neuropsychopharmacology (2012) 37, 2132–2142. On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
  3. http://dx.doi.org/10.1016/j.euroneuro.2015.02.001.Tetrahydrocannabinol alone and combined with cannabidiol mitigate fear memory through reconsolidation disruption
  4. Curr Pharm Des. 2014;20(13):2212-7. Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment.
  5. PLOS ONE December 2012 | Volume 7 | Issue 12 | e49789 . Dimerization with Cannabinoid Receptors Allosterically Modulates Delta Opioid Receptor Activity during Neuropathic Pain
  6. Nature. 2002 Aug 1;418(6897):488-9. The endogenous cannabinoid system controls extinction of aversive memories.
  7. Behav Pharmacol. 2008 Jul;19(4):357-60. Attenuation of anxiety-related behaviour after the antagonism of transient receptor potential vanilloid type 1 channels in the rat ventral hippocampus.
  8. Neurosci Res. 2014 Jul;84:60-3. Intrahypothalamic injection of cannabidiol increases the extracellular levels of adenosine in nucleus accumbens in rats.
  9. Eur Neuropsychopharmacol. 2009 Mar;19(3):188-95. Modulation of anxiety-like behaviour by Transient Receptor Potential Vanilloid Type 1 (TRPV1) channels located in the dorsolateral periaqueductal gray.
  10. J Bone Miner Res. 2015 Mar 19. Cannabidiol, a Major Non-Psychotrophic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts.
  11. J Psychiatr Res. 2012 Nov;46(11):1501-10. Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors.
  12. Psychoneuroendocrinology (2013) 38, 2952—2961  Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks
  13. Braz J Med Biol Res. 1993 Feb;26(2):213-7. Effect of cannabidiol on plasma prolactin, growth hormone and cortisol in human volunteers.
  14. DEPRESSION AND ANXIETY 30:93–96 (2013) THE ENDOCANNABINOID SYSTEM PROVIDES AN AVENUE FOR EVIDENCE-BASED TREATMENT DEVELOPMENT FOR PTSD

 



 
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